December 2nd 2024
Your daily dose of the clinical news you may have missed.
November 27th 2024
A woman in her early 50s presents with 6 hours of right sided pleuritic chest pain. What do the history and ECG suggest? What's yoru Dx?
November 26th 2024
The patient shows no signs of trauma but is a poor historian so no further details are available. Do her vitals or ECG provide any clues to a Dx?
November 25th 2024
November 22nd 2024
Early Detection of CKD Progression in Primary Care: Daily Dose
Semaglutide Lowers CKD-Related Events in Persons with T2D, CKD: Daily Dose
Semaglutide 2.4 mg (Wegovy) Wins Expanded Indication to Include Reduced Risk of MACE
The label expansion for semaglutide, based on the SELECT trial, includes data showing reduced risk of CV death of 15% and of death from any cause of 19%.
New Data Show High Prevalence of Dyslipidemia in American Indian Youth
Few participants with dyslipidemia received lipid-lowering medications despite high prevalence, reported authors of the Strong Family Heart Study.
Underrepresentation of Individuals with CKD in CV Medication Trials Found Persistent Over 2 Decades
Authors: Exclusion of people with CKD from CV medication trials has left significant gaps in understanding the effectiveness of these drugs in a highly vulnerable population.
Migraine, Persistent VMS Tied to Higher Risk of CVD, Stroke: Daily Dose
Plastic Debris Detected in Carotid Plaque Linked to Higher Risk for MI, Stroke, Death
Patients who had microplastics and nanoplastics in their carotid plaque were at more than a fourfold risk for MI, stroke, or death compared to those who did not, according to a new study.
Semaglutide Shows Potential for Significant CVD Prevention: Daily Dose
Zilebesiran Reduces Uncontrolled Hypertension as Addition to Standard of Care in Phase 2 KARDIA-2 Trial
Topline KARDIA-2 findings showed zilebesiran led to clinically and statistically significant reductions in SBP on top of either a diuretic, CCB, or ARB.
Cannabis Use Associated with Higher Risk of MI, Stroke: Daily Dose
Semaglutide Reduces CKD-Related Events by 24% in Population with T2D and CKD: FLOW Findings Announced
Semaglutide 1.0 mg was superior to placebo across the FLOW trial's 5-part primary endpoint with both CKD and CVD components contributing to risk reduction, said Novo Nordisk.
Rapid Progression of CKD Can Be Detected Early Using Simple Markers in Primary Care
The 3-year risk of rapid progression from CKD stage G3 was 15% in a large Danish population. Study authors identified accessible key risk factors to aid early detection.
Migraine and Persistent Vasomotor Symptoms Linked to Higher Risk of CVD, Stroke in Analysis of CARDIA Study
Women with migraine and persistent VMS faced double the risk of CVD and triple the risk of stroke, reported researchers.
Marijuana Use Linked to Higher Risk of Myocardial Infarction, Stroke in New Study
The risk for cardiovascular outcomes increased with more frequent reported cannabis use per month, according to results from a large national study.
Semaglutide Shows Potential for Significant CVD Prevention in Analysis of Real-World Data
Analysis of heart registry data for SELECT trial-eligible adults (obesity, first MI, no diabetes) found an NNT of 49 and 5-year MACE incidence of 10.7%.
Salt Substitute Reduces HTN Risk among Older Adults with Normal BP: Daily Dose
Lowering Out-of-Pocket Rx Costs May Improve Diabetes Outcomes: Daily Dose
Salt Substitute Lowers Risk of Hypertension among Older Adults with Normal Blood Pressure
Older adults with normal BP levels in China were approximately 40% less likely to develop HTN when using a salt substitute for 2 years, according to a new study.
Apixaban and Aspirin Equal in Preventing Stroke Recurrence in Cardiopathy: Daily Dose
New Scientific Statement from American Heart Association Raises Awareness of CVD Risks for Women
Women with adverse pregnancy outcomes face a significantly higher risk of cardiovascular disease and stroke later in life, according to the statement.
Preventive Health Screenings Continue to Lag Post-Pandemic: Daily Dose
Women with Poor Sleep During Midlife at Significantly Elevated Risk for Future CVD
Women aged 40 to 65 years who had persistent insomnia and poor sleep duration were at a 75% greater risk for incident CVD over 2 decades of follow up.
Reducing Out-of-Pocket Rx Costs May Help Improve Diabetes Outcomes, Particularly for those with Lower Incomes
Acute, preventable diabetes complications days fell by 8.4% among participants enrolled in a preventive drug list benefit and by even more among low-income subscribers.
Tirzepatide Linked to “Impressive” BP Reduction in Adults with Obesity: Daily Dose
Apixaban and Aspirin Appear Equal Against Recurrent Stroke in Individuals with Cardiopathy
Anticoagulation and antiplatelet therapy appeared equally effective in reducing risk of recurrent stroke following cryptogenic stroke in persons with evidence of atrial cardiopathy.
Novel Weight Loss Entrant from Amgen Challenges Duration of Effect and Dosing with Wegovy, Zepbound
Amgen's investigational maridebart cafraglutide in a phase 1 trial led to durable weight reduction following less frequent and lower doses, the company said.
Tirzepatide Associated with "Impressive" BP Reduction in Individuals with Obesity
Mean placebo-adjusted SBP change from baseline at 36 weeks was 8.6 mm Hg in adults with obesity, according to authors of the SURMOUNT-1 ABPM substudy.
Apixaban Reduced Risk of Stroke in Subclinical Afib Relative to Aspirin but with Greater Risk of Bleeding: ARTRESIA Trial
In apixaban-treated participants, risk of stroke or systemic embolism was reduced by 37%; the risk of disability or fatal stroke declined by 49%, but with noted bleeding risk.
Risk of Preeclampsia, Preterm Birth Prevented as Well by Low-dose Calcium as by Recommended High-Dose, Study Finds
Low-dose calcium supplementation with 500 mg/day may be as protective against poor pregnancy outcomes as the WHO-recommended dose of 1500 mg/day.
More than Half of US Adults Still Don't Recognize Heart Disease as #1 Cause of Death
Heart disease has been the primary cause of death in the US for the last century, and yet 51% of adults do not recognize the fact.