December 2nd 2024
Your daily dose of the clinical news you may have missed.
November 27th 2024
A woman in her early 50s presents with 6 hours of right sided pleuritic chest pain. What do the history and ECG suggest? What's yoru Dx?
November 26th 2024
The patient shows no signs of trauma but is a poor historian so no further details are available. Do her vitals or ECG provide any clues to a Dx?
November 25th 2024
November 22nd 2024
More than Half of US Adults May Be Eligible for Semaglutide Therapy, Accordng to New Estimates
Millions of US adults could benefit from semaglutide treatment for diabetes, obesity, and/or CV disease but insurance isn't guaranteed and the drug is costly.
Investigational Oral Agent Muvalaplin Reduces Lp(a) by Up to 85% in High-Risk Adults: Phase 2 Data
Lp(a) is a genetically-driven and independent risk factor for CVD with no approved treatments. Lilly is advancing muvalaplin and has some good competition.
Intensive SBP Reduction Below 120 mm Hg Reduces MACE in Adults with Type 2 Diabetes
AHA 2024. Findings from the BPROAD trial help fill a gap left by similar studies on the ideal target SBP for adults with type 2 diabetes, said study authors.
Aprocitentan Now Available in the US for Treatment-Resistant Hypertension
Aprocitentan is the first-and-only dual endothelin receptor antagonist approved for the treatment of systemic hypertension.
Death Rates from Obesity-Related Heart Disease Soared Nearly 200% Between 1990 and 2020, Researchers Report
AHA 2024. "...we did not anticipate this magnitude of increase in mortality," researchers said. They were also surprised by the population groups most affected.
Semaglutide 2.4 mg Reduces Risk for Hospitalization for Any Cause in Adults with CVD, Obesity
ObesityWeek 2024. Semaglutide 2.4 mg reduces rates of composite CV outcomes in high-risk patients without diabetes and now is shown to reduce inpatient care and length of stay.
Oral Semaglutide Linked to Lower Risk of MACE: Daily Dose
Oral Semaglutide Shows 14% Reduction in MACE in Adults with T2D, ASCVD, and/or CKD: Topline Results from Phase 3 SOUL Trial
Novo Nordisk plans to file for regulatory approval this year of an expanded label for oral semaglutide, with an indication for reduction of MACE in high-risk adults with T2D.
Why Are Women Still Missing from Cardiovascular Clinical Trials?
Women remain underrepresented in heart disease research after decades of efforts to correct the balance, affecting trial data and women's cardiovascular care.
COVID-19 Linked to Long-Term Risk of MACE, Especially Among Adults with non-O Blood Types
Prior SARS-CoV-2 infection was associated with a 2-fold increased risk for MACE for up to 3 years, even among people with no history of CVD, in a new analysis of UK Biobank data.
Better CV Health in Early Pregnancy Offsets High Genetic Risk: Daily Dose
Atrial Fibrillation More Prevalent in US Than Previously Estimated: Daily Dose
Strong Link Between Increasing Lp(a) Level and Recurrent ASCVD Events Makes Screening Essential, Investigator Warns
A continuous increase in ASCVD risk was seen with higher levels of lipoprotein(a) in the largest study to date of the relationship.
Over Half of US Adults with Uncontrolled HTN Unaware of Their Condition: Daily Dose
Resistant & Refractory Hypertension: 9 Questions for Primary Care
How are you managing your patients with resistant or refractory hypertension? How do your strategies align with current guidelines? Try these 9 questions and find out.
Resistant and Refractory Hypertension: A Guideline Topline for Primary Care
Hypertension that is resistant or refractory to treatment increases the risk of comorbidity and cardiovascular risk. Click through this at-a-glance review of key issues.
Recent Recreational Drug Use Ups Risk of Repeat Serious CV Event: Daily Dose
Good Cardiovascular Health Early on May Offset Genetic Risk of Hypertensive Disorders of Pregnancy
New data shows that favorable CV health in the first trimester is associated with a 35% to 62% lower risk of HDP regardless of level of genetic risk.
Awareness of Uncontrolled Hypertension Low, Particularly Among Young Adults, Study Warns
Unawareness was highest among the youngest adults, aged 18 to 44 years, an age range where CV health should be optimized to avoid later morbidity, researchers wrote.
Atrial Fibrillation in the US 3-Fold More Prevalent Than Previously Estimated, New Data Suggest
Approximately 10.5 million US adults, or 5% of the population, have the atrial fibrillation, according to new prevalence estimates.
Statin Plus Ezetimibe Outperforms High-Dose Statins in LDL-C Reduction: Daily Dose
CPAP Treatment and Hypertensive Adverse Outcomes in Pregnancy: Daily Dose
Finerenone Improves Outcomes in Patients with Heart Failure and Mildly Reduced or Preserved Ejection Fraction
ESC 2024: Findings from the FINEARTS-HF clinical trial provide the first definite evidence that an MRA can be beneficial in patients with HFmrEF/HFpEF.
Recreational Drug Users Face Triple the Risk of Repeat Major Adverse CV Events vs Non-Users
ESC 2024: Cannabis, opioid, and MDMA use were most strongly tied to cardiovascular event risk, according to a new study.
Plant-Based Fats Reduce Risk for Overall, CVD Death: Daily Dose
Tirzepatide Tied to Lower Risk for Death, Adverse CV and Kidney Outcomes vs GLP-1s: Daily Dose
Combination Statin Plus Ezetimibe More Effective than High-Dose Statin to Reduce LDL-C in People with ASCVD
In secondary CVD prevention, low/moderate-dose statins plus ezetimibe were superior to high-dose statin for reducing biomarkers, myalgias but did not reduce MACE.
Effectiveness of Anti-Obesity Drugs for CVD Prevention: A Clinician Discussion
Anila Chadha, MD, talks to Patient Care about how antiobesity medications can aid in reducing CVD risk in patients with obesity.
Cardiovascular Disease Prevention in Patients with Obesity: An Expert Perspective
Anila Chadha, MD, highlights key preventive strategies to reduce CVD risk in patients with obesity and how to tailor them to address individual patient needs.
White Coat & Masked Hypertension: A Primary Care Guideline Topline
White coat and masked hypertension can be elusive and dangerous. Click through a topline look at recommendations from the 2017 ACC/AHA hypertension guidelines.