December 4th 2024
Your daily dose of the clinical news you may have missed.
December 2nd 2024
November 27th 2024
A woman in her early 50s presents with 6 hours of right sided pleuritic chest pain. What do the history and ECG suggest? What's yoru Dx?
November 26th 2024
The patient shows no signs of trauma but is a poor historian so no further details are available. Do her vitals or ECG provide any clues to a Dx?
November 25th 2024
Distinct Patterns of BP in Early Gestation Predict Hypertensive Disorders: Study
Investigators identified 6 blood pressure patterns that, when combined with other risk factors, accurately stratified risk of hypertensive disorders of pregnancy.
Diabetes- and CVD-Related Mortality Rise after Steady 10-Year Decline
Since 2014, the age-adjusted mortality rate for diabetes and CVD has increased by 1% after an overall decline between 1999 and 2019, new research finds.
Concentrated and Distributed Physical Activity Similarly Lower Risk for CV Events
Regardless of the pattern of physical activity, it may reduce risk across a spectrum of cardiovascular diseases, say study authors. So, just do it!
Daily Dose: Preoperative HIIT and Cardiorespiratory Health Among Adults Undergoing Major Surgery
Your daily dose of clinical news you may have missed.
Women with Acute Ischemic Stroke Routed Less Often to Optimal Acute Care
Disparities in emergency routing persisted despite women being acutely sicker than men and living the same distance from a comprehensive stroke center, in a Houston, Tx study.
When Statin Guidelines Collide: 5 Questions on 2 Approaches to Primary CVD Prevention
Guidelines on primary ASCVD prevention from the USPSTF and the AHA/ACC/Multisociety differ on why and when to initiate a statin. Try the 5-question quiz.
Early Signs of Atherosclerosis Found in Young Tobacco and E-Cigarette Users
Young adults who smoke tobacco cigarettes or vape showed early signals of atherosclerosis compared with nonsmokers in a small, cross-sectional study.
For the Statin-Intolerant or Statin-Unwilling Patient, Part 2: Other Pharmaceutical Options
For the 1 in 3 individuals with hyperlipidemia who can't or won't take a statin, preventive cardiologist Elizabeth Klodas, MD, details 3 alternative drug classes.
New Research Suggests Preoperative High-intensity Interval Training is Beneficial for Cardiorespiratory Health
Findings from meta-analysis showed preoperative high-intensity interval training was associated with improvements in exercise capacity and a reduction in postoperative complications.
Less than Half of Patients with New AF Diagnosis Prescribed Oral Anticoagulation within 6 Months
Factors positively associated with a timely first OAC Rx among the 41.3% who received one included male sex, certain comorbidities, other current medications, and obesity.
When Statins Are Not an Option, Part 1: Leverage Nutrition First
Preventive cardiologist Elizabeth Klodas, MD, reviews the essential elements of a plan of eating shown clinically to reduce hyperlipidemia.
Back Pain on Eliquis: Seen in the ED
The 72-year-old woman says the back pain came on earlier in the evening without injury or heavy lifting and radiates slightly to her left leg. What does the MRI show?
Choosing Between Guidelines: Statins for Primary CVD Prevention
In a recent comparison of guideline recommendations for initiating statin therapy in primary prevention, researchers found significant differences in the numbers who would benefit.
Daily Dose: Association of Population Wellbeing with Cardiovascular Outcomes
Inclisiran Label Expanded to Include Primary Prevention Population
The expanded indication widens the patient population eligible for the novel siRNA therapy to include high-risk patients on maximum statin Rx who have not had a CV event.
Daily Dose: Vitamin D Supplementation and Major Cardiovascular Events in Older Adults
Statins Appear Beneficial for CV Outcomes in Primary Prevention Patients with HTN without CVD or Diabetes
In a study of over 26 000 participants, statin use was associated with reduced risk for all-cause and CV mortality compared to placebo.
Daily Dose: Loneliness and CVD Risk in Patients with Diabetes
Higher Community Wellbeing Linked to Reduced CVD Mortality in Study of More than 3000 US Counties
Wellbeing is considered a measurable and modifiable community attribute that study authors show is correlated with CV outcomes.
US Maternal Mortality Doubled 1999-2019, Remains Highest Among Black Women
The greatest increase over the 10 years was seen in deaths among American Indian and Alaska Native women, according to Institute for Health Metrics and Evaluation data.
Monthly Vitamin D Supplementation May Lower the Risk of Major CV Events in Older Adults
Vitamin D supplementation may reduce the incidence of major cardiovascular events in older adults, suggests new research.
Daily Dose: Pegozafermin in Patients with NASH
Loneliness Linked to Greater Risk for CVD in Individuals with Diabetes
The predictive value of loneliness for cardiovascular disease in patients with diabetes was stronger than traditional lifestyle risk factors in large UK Biobank analysis.
Pegozafermin Shows Early Promise in NASH: Phase 2b ENLIVEN Trial Findings
Pegozafermin, an investigational long-acting (FGF21) analogue, was associated with fibrosis improvement and NASH resolution in an average of 25% of study participants.
E-Cigarettes: US Sales Nearly Double over 2 Years, Youth Prefer Flavored Disposables
Sales of e-cigarettes in the US jumped by 46% from 2020-2022; rapid market shifts beg coordinated restrictions to protect public health, says the CDC.
Daily Dose: HF, CV Benefit of SGLT-2 Inhibition Consistent in T2D, CDK, HF
Studies of Novel, Highly Effective Antiobesity Medications Headline 83rd ADA Scientific Sessions
Retatrutide, survodutide, orforglipron. The 3 new GLP-1 agonist-based AOMs showed weight loss of up to 20% and are well worth watching.
Daily Dose: Bempedoic Acid Reduces Risk for MACE in Primary Prevention Population
Bempedoic Acid Reduced Risk for MACE by 30% in Primary Prevention Population: CLEAR Outcomes Subanalysis
ADA 2023: The only nonstatin therapy to reduce risk for 4-point MACE in ASCVD may potentially find a role in primary prevention as well, though caution is advised.
SGLT-2 Inhibitor HF, CV Benefit Found Consistent Across Populations with T2D, CKD, HF
SGLT-2 inhibitors were found to consistently reduce risk of CV mortality and HF events in a meta-analysis including 90 000 high-risk patients with T2D, CKD, and/or HF.