November 11th 2024
Insights on how to manage the "triple threat" of flu, RSV, and COVID-19 this season.
October 31st 2024
Your daily dose of the clinical news you may have missed.
October 29th 2024
Preliminary phase 1 data showed that RSV neutralizing antibodies for non-adjuvanted SCB-1019 matched GSK’s AS01E-adjuvanted RSV vaccine, Arexvy.
October 9th 2024
Data on adults aged 60 years and older who received a single dose of the RSV vaccine indicate safety and reactogenicity consistent with the overall GSK phase 3 trial program.
October 8th 2024
Biologic Therapy for Asthma & COPD: 8 Questions on Targets, Pathways, & mAbs
Research into biologic therapy for asthma and COPD has been both successful and frustrating. Find out what you know about the progress with these 8 questions.
Chronic Diseases in Multimorbidity May Share Origins, Study Finds
Using metabolomic profiling from more than 11 000 individuals, researchers identified common pathways linking seemingly unrelated diseases that often co-occur.
COPD Outcomes Improve with Triple Therapy, Regardless of Exacerbation History
Post-hoc analysis of the phase 3 KRONOS study concluded that the benefits in COPD exacerbation seen were not driven by the small subgroup with a prior history of exacerbations.
Are Biologics for COPD Around the Corner? A Quick Look at the Literature
No biologic agent is approved to treat COPD, but progress is being made. Key developments of the past few years are summarized in this brief slideshow.
Hyaluronan Improves Respiratory Failure in Acute Exacerbation of COPD
Hyaluronan represents a new class of biologic that significantly improves lung health in patients with severe COPD.
COPD Diagnosis in Primary Care: 6 Essential Facts
Most diagnoses of COPD are made in the primary care setting. Try these 6 questions to see what you know about the essentials of the differential diagnosis.
Asthma, COPD, & Asthma-COPD Overlap: A Quiz in Differential Diagnostics
Distinguishing asthma and COPD can at times be problematic and the asthma-COPD overlap picture is even less clear. Check your recall of GINA/GOLD guidelines on all 3.
Passive Smoke Exposure in Childhood May Cause Subclinical LV Dysfunction in Adults
AHA 2020 Virtual Scientific Sessions: Cumulative exposure, exposure intensity, and number of household smokers in childhood all impact adult heart function, study authors found.
Tezepelumab for Severe Asthma Meets Phase 3 Primary Endpoint
The novel monoclonal antibody could bring relief to millions of persons with severe, uncontrolled asthma, including those with a low eosinophil phenotype.
COPD Self-management App Reduces Exacerbations, Readmissions vs Usual Care
Use of the myCOPD app after hospitalization for acute COPD exacerbation reduced subsequent exacerbations by nearly 50%, according to study authors.
CVD Mortality in COPD Related to Factors Other than Lung Function Decline
In COPD patients, a new study found no association between lung function decline and individual CVD outcomes, but disease exacerbations and dyspnea were implicated.
Genetic Mutations May Underlie Severe COVID-19 Illness
More than 10% of those who develop severe COVID-19 have misguided antibodies that derail the immune response, according to new research.
Asthma: Long-acting Muscarinic Antagonists Overused, Up Exacerbation Risk
Long-acting muscarinic antagonists, recommended as add-on therapy for asthma, are too often used as monotherapy and are linked with severe exacerbations, a new study finds.
“Social Smoking” Linked to Disproportionately High Risk of Death from Lung Disease, Lung Cancer
New research presented at the virtual European Respiratory Society International Congress showed "social smokers" are more than twice as likely to die of lung disease vs non-smokers.
NIH COVID-19 Treatment Guidelines Updated Based on New Data
Treatment guidelines on COVID-19 from the NIH were updated today based on data from clinical trials of hydroxychloroquine, ivermectin, and IL-6 inhibitors.
ACIP Revises Adult Pneumococcal Vaccination Recommendations: Good, Bad, and Ugly
The ACIP, once more, revised its recommendations for administration of pneumococcal vaccination among adults aged ≥65 years. Is there a lesson learned here?
US Adolescent E-cigarette Users at Increased Risk for COVID-19
A new survey found adolescents who have ever used e-cigarettes are 5-times more likely to receive a COVID-19 diagnosis. More results at-a-glance in our new slideshow.
Remdesivir New Drug Application Submitted to FDA
The investigational antiviral remdesivir in phase 3 clinical trials led to faster time to recovery vs placebo and was found to be safe.
Fever and Headache, then Cough, in a 52-year-old Woman
Patient's vital signs and results of physical examination are normal; results of a previous lumbar puncture also were normal. What does the chest x-ray reveal?
FDA Approves Triple Fixed-dose Inhaled Therapy for COPD
Approval was awarded to AstraZeneca for an inhaled, fixed-dose combination of budesonide/glycopyrrolate/formoterol fumarate.
Study: After COVID-19, Symptoms Persist for Majority of Patients
JAMA: After recovery from COVID-19, a majority of patients reported persistence of at least 1 symptom; more than half reported ≥3 symptoms.
Reducing Risk of Severe Dyspnea-related Psychological Trauma in COVID-19 Survivors
Prolonged "air hunger" induced during mechanical ventilation for severe COVID-19 infection can be eliminated by a change in standard of care, a new paper suggests.
Asthma, COPD Inhaler Adherence Up During Pandemic
Adherence to controller medication appears to have increased between early January and late March among patients with asthma and COPD, finds a new study.
Vaping-related Hospitalization, Mortality: A Quiz on New CDC Guidance
Try your hand at these 8 questions based on the latest CDC guidance on rehospitalization and mortality in patients with vaping-related lung injury.
3 Strategies to Optimize Facemask Supply: Conventional, Contingency & Crisis Plans
The CDC outlines 3 surge capacity strategies to help healthcare providers prioritize COVID-19-related conservation of facemasks: conventional, contingency, and crisis.
4 Lung Disease Study Briefs for Primary Care
Testosterone could protect women from asthma and niacin may decrease COPD severity in men--results of 2 of these 4 studies. Read more.
Stroke Risk Nearly Triples with Dual Vaping, Combustible Cigarette Use
A new study found a significant association between increased stroke risk and dual use of e-cigarettes and traditional cigarettes-authors urging physicians to use results as a wake-up call.
Managing EVALI Patients during Flu Season: 6 CDC Recommendations
These 6 recommendations from the CDC can aid physicians in differential diagnosis and treatment of EVALI and the flu.
Vaping-Related Lung Injury: New CDC Recommendations for Primary Care Physicians
The multistate outbreak of vaping-related lung injury is ongoing, but the CDC's updated interim guidance can help physicians navigate the clinical evaluation and management of these patients.
Vaping-Related Lung Injury in the US: A Pop Quiz
How current are you on the outbreak of lung injuries associated with e-cigarette use, as of today? Take our pop quiz on the latest facts and figures to find out.