December 18th 2024
The 2 novel vaccine candidates each combine a Sanofi licensed influenza vaccine with the Novavax adjuvanted recombinant COVID-19 vaccine.
Your daily dose of the clinical news you may have missed.
December 4th 2024
Many unvaccinated adults reported intent to get vaccinated, according to early season estimates released in MMWR.
A woman in her mid-50s arrives at the ED for suspected anaphylaxis; SOB has not responded to epinephrine and steroids. Does the CT scan suggest a Dx?
November 11th 2024
Insights on how to manage the "triple threat" of flu, RSV, and COVID-19 this season.
A Vaccination Imperative: "Please, Let's Do It," NFID Medical Director Robert Hopkins, Jr, MD, Urges
The National Foundation for Infectious Diseases medical director appeals to the community at large to set politics and personal grievance aside and to "first, do no harm."
10 Essential Vaccine Updates for Primary Care: Winter 2024-2025
From ACIP updates on age eligibility and research on vaccine efficacy to US adults' attitudes toward recommended shots, these 10 at-a-glance news briefs are must-reads for PCPs.
Expert Perspectives 2024: Biologics for Management of COPD with MeiLan K Han, MD, MS
The GOLD report committee member highlights advances in knowledge of COPD phenotypes and the new role for biologic medications in this year's video series.
The Biggest Challenge with COVID-19 Right Now: An Interview with NFID Medical Director Robert Hopkins, Jr, MD
Hopkins, of the National Foundation for Infectious Diseases, is frustrated by the diminished societal response to the virus' circulation including ongoing low vaccination rates.
New COVID-19 Vaccination Guidance for Older Adults & High-Risk Groups: A Conversation with NFID Medical Director Robert Hopkins, Jr, MD
Guidance from the Advisory Committee on Immunization Practices on best practices for COVID-19 vaccination continues to evolve, Hopkins explained.
"Be Vigilant About Risk Factors for COPD, Aggressive with Questions About Symptoms," Expert Advises Primary Care
COPD expert MeiLan K Han, MD, MS, says that in the absence of a definitive single tool to assess for COPD, probing patients for risk factors and symptoms is essential.
2025 GOLD Report on COPD Addresses Cardiovascular Risk in New Section: MeiLan Han, MD, MS, Highlights Rationale
Cardiovascular comorbidities in adults with COPD are linked to poor outcomes including reduced QoL, increased hospitalizations, and greater risk of mortality, Han explains.
Social, Racial Disparities in Flu, COVID-19, RSV Vaccine Uptake: Daily Dose
Investigational RSV Vaccine Yields Positive Preliminary Data in Head-to-Head Comparison with Arexvy
Preliminary phase 1 data showed that RSV neutralizing antibodies for non-adjuvanted SCB-1019 matched GSK’s AS01E-adjuvanted RSV vaccine, Arexvy.
New Data Highlight Social, Racial Disparities in Flu, COVID-19, RSV Vaccine Uptake
IDWeek 2024: Black individuals were less likely to be vaccinated against all 3 respiratory viruses than White individuals, according to new research.
New Data for Arexvy Show Vaccine Efficacy Through 3 RSV Seasons in Older Adults
Data on adults aged 60 years and older who received a single dose of the RSV vaccine indicate safety and reactogenicity consistent with the overall GSK phase 3 trial program.
FDA Approves First-Ever Biologic Medicine for COPD: Daily Dose
Albuterol/Budesonide Reduces Risk of Exacerbation in People with Intermittent, Mild-Persistent Asthma
Albuterol/budesonide (Airsupra) has now proven effective as novel combination as-needed rescue medication for adults with asthma regardless of disease severity.
RSV Mortality Higher than for Influenza B 90 Days After Hospital Discharge: New Data
Older adults hospitalized with RSV were older, more frail, and more likely to have respiratory comorbidities than those with influenza A or B, the study found.
FDA Approval of Dupilumab for Uncontrolled COPD will Change the Treatment Landscape: Interview with Surya Bhatt, MD, MSPH
Surya Bhatt, MD, MSPH, is coprincipal investigator for the 2 pivotal phase 3 clinical trials that supported today's landmark FDA approval of dupilumab for COPD.
Dupilumab Becomes First Biologic Approved in the US as Targeted Therapy for Adults with COPD
Dupilumab represents the first new treatment approach for uncontrolled COPD in more than a decade and reduced disease exacerbations by 34% in clinical trials.
IPF Update: FIBRONEER-IPF Study of Nerandomilast Meets Primary End Point
The positive pivotal phase 3 trial results showed improved lung function with neradomilast vs placebo and will support BI's US and global NDA submissions.
FDA Approves Dupilumab Label Expansion with Indication for CRSwNP in Adolescents
The approval makes dupilumab available to treat uncontrolled CRSwNP in adolescents aged 12 to 17 years, expanding on the current approved range of 18 years and older.
Pfizer Reports Topline Data for Abrysvo Against RSV in Younger High-Risk Adults
RSVPreF induced strong neutralizing responses in immunocompromised adults aged 18 years and older in substudy B of the ongoing phase 3 MONET clinical trial.
Long Colds: How to Manage Patient Expectation About Duration of the Common Cold
Patients largely underestimate how long a cold should last and the lingering symptoms too often prompt a request for antibiotics. Primary care, please resist!
ME/CFS Rates No Different After COVID-19 Infection than After Other Acute Infection-Like Illnesses
The rate of ME/CFS was similar (3% to 4%) at 3 through 12 months for study participants who tested positive and negative for COVID-19.
Respiratory Virus Vaccines: AAFP Board Chair on Patient Eligibility, How to Combat Misinformation this Season
Encouraging patients to reach out with questions may lead more to roll up their sleeves this season, Tochi Iroku-Malize, MD, told Patient Care.
Respiratory Virus Vaccine Update: AAFP Board Chair Details ACIP 2024-25 Recommendations
Tochi Iroku-Malize, MD, discusses the ACIP's updated recommendations for immunization against COVID-19, influenza, and RSV.
FDA Gives Green Light to Ensifentrine for Maintenance Treatment of COPD in Adults
The dual PDE3/PDE4 inhibitor is the first inhaled product with a novel mechanism of action approved for COPD in 2 decades and is delivered via standard jet nebulizer.
Investigational Influenza-COVID-19 Combination Vaccine Elicits Immune Response in Older Adults: Daily Dose
Phase 3 Trial of Combination Flu/SARS-CoV-2 Vaccine Meets All Primary Endpoints: Moderna
The investigational combination vaccine elicited higher immune responses vs licensed comparator vaccines in 2 independent age groups, the company said.
FDA Approves First mRNA Vaccine Against RSV for Adults Aged ≥60 Years: Daily Dose
FDA Approves Moderna's mRESVIA, First mRNA Vaccine Against RSV, for Adults Aged ≥60 Years
mRESVIA is Moderna's second mRNA-based vaccine and will be shipped in prefilled syringes, a desirable feature that could save clinical time, prevent errors.
Tezepelumab Found to Reduce Rate of COPD Exacerbations in Persons with Wide Range of Blood Eosinophil Levels: Daily Dose
Find and Treat Asthma and COPD: All Interventions Make a Difference, Study Concludes
Adults with undiagnosed asthma or COPD who were randomly detected and assigned to specialist or usual care all had improved outcomes at 1 year, Canadian authors reported.