Rheumatology

In the open-label, phase 1 study, participants' own T cells will be extracted and engineered to target and eliminate autoreactive B cells and to potentially reset the immune system.

The man in his early 70s complains of leg pain lasting a month and of arm pain that came on about 1 week ago. Does the x-ray offer a clue to a diagnosis?

Findings from a recent study show a broad spectrum of possible clinical manifestations of IRD following SARS-CoV-2 infection or COVID-19 vaccination.

Your daily dose of clinical news you may have missed.

Patients with rheumatoid arthritis and fibromyalgia were at the greatest risk of transitioning to long-term opioid use 1 year after a first prescription, a new study found.

Allopurinol exposures of 100 mg or more than 100 mg were associated with lower odds of first-ever ACS with some differences between sexes, a new study reports.

New findings from a national survey shed light on patient attitudes and experiences with arthritis and joint pain.

Findings from the University of Michigan National Poll on Healthy Aging highlight the need for clinicians to raise the topic of joint pain with their older patients.

Racial disparities in gout prevalence could be explained by diet, social determinants of health, kidney disease, and other factors that suggest interventions.

Excess adiposity and genetic predisposition both were found to be associated with a higher risk of gout, particularly among US women, in a new prospective study.

The approval represents the first new treatment for generalized systemic lupus erythematosus in over a decade.

A recent meta-analysis assessed comparative clinical efficacy of NSAIDs and COX-2 inhibitors. Try these 7 questions on the findings - does your clinical experience match?

Opioids or opiate-like analgesics? Weight loss, exercise, or orthotics? Sleep interventions or cognitive therapy? What works for OA pain and what's the evidence?

Special Report recap: the current and future state of RA patient care and what PCPs will need to know to do their part.

Preventing further acute attacks and decreasing the tophi burden becomes a secondary goal.

Primary care can do more to help reduce gout morbidity, says a new review-plus 4 more studies on gout treatment and prevention.

The faster the attack is recognized and treated with medications, the easier it is to control.

Clinical presentation, history, and laboratory evaluation can make a diagnosis of gout, but crystal examination is the “gold standard.”

How to regulate “the king of diseases and the disease of kings” is this Patient Care Special Report's domain.

The 60-year-old black woman has a history of joint pain, muscle weakness, and Raynaud phenomenon. Why the “dirty hands”?

The patient’s reach with his thumb helps distinguish between frozen shoulder and osteoarthritis. How high is enough to tell?

For key facts and figures about musculoskeletal disorders, perhaps a surprise as the fourth leading diagnostic category in primary care, see the pages that follow.

Can you identify the most common symptoms of Löfgren syndrome ?

Once a disease of kings, gout affects an increasing number of “commoners”-and the physical and economic toll is high.

What condition is represented by inflammatory muscle disease, interstitial lung disease, Raynaud phenomenon, arthritis, and cutaneous manifestations, and in what rheumatologic diseases might you see it?

Oral etidronate, IV pamidronate, and then zoledronate caused bone markers to normalize in this 80-year-old woman-temporarily. What’s going on? Answer this and questions on 3 other topics in this week’s quiz.

The “shawl sign” and the heliotrope rash: two skin signs that are pathognomonic of dermatomyositis. Here: a close-up look.

Polycystic ovary syndrome, “dermatoses of pregnancy,” systemic sclerosis, subacute cutaneous lupus erythematosus, gallbladder agenesis, sarcoidosis-a close look at medical problems seen frequently in women.

A 5-year-old boy had pain and weakness in his legs and had trouble climbing stairs. He had a dramatic rise in CPK followed by erythematous papules on the hands, as shown, and a rash around the eyelids. Which diagnosis is most likely?

Test yourself on symptoms of Löfgren syndrome, comorbdities of Down syndrome; complications of diabetes, and more in this week’s quiz.