HIV AIDS

Research Focus: Recent Developments in HIV Therapeutics

Antiretroviral Therapy: Darunavir: An Overview of an HIV Protease Inhibitor Developed to Overcome Drug Resistance

Case Report: Cytomegalovirus Encephalitis in an HIV-Seropositive Person

Editorial Comment: Impact of Darunavir for Salvage Therapy

From the Editor's Desk: In This Month's Issue

A 34-year-old woman who was coinfected with HIV and hepatitis C virus complained of acute abdominal pain and generalized pruritus of 3 weeks' duration. She was noncompliant with her antiretroviral medications.

This infection is caused by reactivationof varicella-zoster virus (VZV),which may remain latent in thedorsal root and cranial nerve gangliafor decades. Reactivation oftenoccurs for no apparent reason, althoughstress and immunosuppressionmay increase the risk.

ABSTRACT: A 4-pronged approach that includes patient education, skin and nail care, appropriate footwear, and proactive surgeries can effectively prevent diabetic foot problems. Teach patients with diabetes to examine their feet daily to detect new onset of redness, swelling, breaks in the integrity of the skin, blisters, calluses, and macerated areas. Have them follow a daily foot care regimen that includes warm water soaks and lubrication, and have them keep toenails properly trimmed. Recommend that patients select shoes that fit properly and have sufficient padding and toe box space; have them use inserts, lifts, orthoses, or braces--as recommended-to correct abnormal gait patterns. Finally, if deformities develop, simple proactive surgical procedures can correct these problems before they result in the development of wounds.

Images in HIV/AIDS: HIV-Associated Lymphogranuloma Venereum Proctitis

LOS ANGELES -- An investigational anti-HIV drug called maraviroc, the first CCR5 inhibitor, significantly outperformed placebo in patients who were failing anti-retroviral therapy, according to interim results from two major phase III trials.

LOS ANGELES -- Like the traditional HIV-associated opportunistic infections, the toll of conditions such as heart and liver disease is affected by the immune status of a patient, researchers reported here.

LOS ANGELES -- Raltegravir (MK-0518), an investigational anti-retroviral drug that targets the HIV enzyme integrase, seems highly effective in patients resistant to existing classes of drugs.

LOS ANGELES -- An investigational synthetic hormone significantly reduces visceral fat in patients treated for HIV, researchers reported here.

LOS ANGELES -- Interrupting antiretroviral therapy for HIV patients increases the risk of cardiovascular disease by more than 50% over four years, a British researcher said here.

LOS ANGELES -- Extensively drug-resistant tuberculosis -- or XDR-TB -- is appearing in more countries and is estimated to have caused 16,000 deaths in 2005.

HOMBURG, Germany -- There is a quick, reliable way to assess sepsis and overall prognosis in secondary peritonitis, according to researchers here.

CHICAGO -- The verdict on male circumcision and HIV transmission has been validated. Now the question is how to implement the finding that male circumcision cuts the risk of HIV infection by more than 50%.

LONDON -- Treating herpes simplex with valacylovir (Valtrex) reduces the levels of HIV in women who are infected with both viruses, according to researchers here.

BETHESDA, Md. -- An atomic-level snapshot of a key HIV protein as it binds to a neutralizing antibody, a feat accomplished here, may be a step toward an effective vaccine, the researchers said.

SAN FRANCISCO -- Smoking marijuana significantly reduces nerve pain associated with HIV infection, according to researchers here.

SAN FRANCISCO -- A transcutaneous electrical nerve stimulation (TENS) device used in stroke rehabilitation clinics may be effective for home use as well, researchers said here.

TOTTORI, Japan -- A third of patients with hepatitis C infections and hepatic fibrosis could be spared liver biopsies by the use of a new index that predicts significant fibrosis with three blood tests, according to researchers here.

ARLINGTON, Va. -- For the second time, efforts to create a topical microbicide that would protect against HIV transmission during sex have ended in failure.

Herpes zoster occurs in 10% to 20% of the general population as a result of reactivation of the varicella-zoster virus (VZV) and is generally benign. It occurs more frequently in persons with cellular immunodeficiency and older age. The association between herpes zoster and HIV was confirmed early in the course of the HIV epidemic by numerous studies. Zoster was noted to precede AIDS in high-risk groups. Both the incidence and complication rate of herpes zoster are increased in HIVinfected patients.

Fanconi syndrome is generally characterized by evidence of proximal renal tubulopathy (ie, decreased renal reabsorption and increased urinary excretion of filtered proteins, potassium, glucose, phosphate, amino acids, and calcium).