John N. Greene, MD

Opportunistic fungal infections are increasingly common inpatients who undergo hematopoietic stem cell transplant(HSCT). Voriconazole is frequently used in allogeneicSCT recipients who receive immunosuppressant therapy forgraft versus host disease to prevent invasive aspergillosis.Indications for voriconazole use include invasive aspergillosis,candidemia, Scedosporium apiospermum infection, and fusariosis.We describe a case in which disseminated Fusarium infectiondeveloped in an HSCT recipient who was receiving voriconazoletherapy. [Infect Med. 2008;25:528-530]

Recognition of a simultaneous viral and bacterial skin infectioncan be challenging. In the case presented here, an immunocompromisedpatient presented with a painful rash on the arm,pustules and papules on the chest, and crusted lesions onthe nares. Culture and immunofluorescent staining revealedStreptococcus and varicella-zoster virus, respectively. Afterappropriate treatment, the rash completely resolved. [InfectMed. 2008;25:240-241]