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Early Identification of Alzheimer's Disease

Adult Immunization Center

Dermatology Hot Topics

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ACT EARLY, ACT NOW: A Practical Guide to Early Identification of Alzheimer’s Disease

The mother of a 10-year-old boy brings him in for evaluation of his moles (which are all benign). During the visit, the mother asks about the lesions on the first 2 knuckles of his right hand; she initially noticed them several months earlier. The boy is otherwise healthy.

Clinical Topics

White Knuckles

A 5-year-old boy with a history of atopic dermatitis since 6 weeks of age, presents with a rash around his mouth that has been present for approximately 1 year. The patient’s mother reports that desonide topical cream was applied to the affected area for about 5 days, which initially resulted in improvement, however the rash returned after this medication was discontinued. The rash also recently improved after the patient took amoxicillin for an infection. She also notes that the patient has been licking his lips more frequently.

On examination there is an erythematous papulopustular eruption restricted to the perioral region, with sparing of the vermillion border. Mild hyperpigmentation is noted on the patient’s neck. There is no active involvement of other areas of the body.

The eruption has been present for 1 year and is restricted to the perioral region. What is included in your differential? 

Rash Around the Mouth of a 5-year-old Child

A 9-year-old boy presented with a 1-week history of pruritus and rash on his elbows, knees, back, and legs. Several areas of excoriation were noted. He had recently run through a field of tall grass but denied any other exposure history.

A 9-year-old boy presented with a 1-week history of pruritus and rash on his elbows, knees, back, and legs. He had recently run through a field of tall grass but denied any other exposure history. Your Dx?

What Cause of This Itchy Rash?

Dermatologist Elizabeth Swanson, MD, discusses the recent resurgence of the measles virus and stresses the efficacy and safety of the measles vaccine

Measles Resurgence and Vaccine Efficacy: A Conversation with Elizabeth Swanson, MD

The re-emergence of measles was a topic Elizabeth Swanson, MD, highlighted during her session "Big Rashes in Little Patients" at the 2025 American Academy of Dermatology meeting in Orlando, Florida. The latest US 

 show that a total of 301 cases of measles have been confirmed in the US as of March 13, 2025. With current vaccination rates across the US falling below the 95% threshold needed for herd immunity, measles outbreaks are likely to become more common across the US, not just in isolated areas. "So, while West Texas is dealing with this outbreak right now, the rest of the United States is certainly not immune to it," Dr Swanson told 

via Zoom. "We're going to start seeing pockets of it across the country unless vaccination rates improve." 

In the video above, Dr Swanson also addresses vaccine safety, emphasizing the importance of relying on scientific evidence rather than misinformation.

Dr Swanson discusses the resurgence of measles and emphasizes the safety and efficacy of the measles vaccine.

A 47-year-old man presents c/o swelling in extremities-hands x1 week; legs, x1 month. Marked tumescence is seen in the hands and pitting edema is noted on lower legs. PMH: HTN, T2DM, hyperlipidemia; S/P cholecystectomy. Meds: HCTZ; lisinopril; amlodipine; insulin. See differential diagnosis below.

VIDEO: Note marked tumescence in patient’s hands, pitting edema in lower extremities. Does PMH contribute? Dx?

A 47-year-old Man with Peripheral Edema 

A 67-year-old woman noted the appearance of several non-tender, rock-hard, purple-colored nodules on her legs. Her medical history was significant for distant non-Hodgkin lymphoma.

A 67-year-old woman noted the appearance of several non-tender, rock-hard, purple-colored nodules on her legs. Her medical history was significant for distant non-Hodgkin lymphoma. The violaceous color and configuration of the skin lesions suggests which of the following? 

Hard Purple Nodules: Your Dx?

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