Guillan Barré and Vaccines: Cause or Coincidence?

Poll

Is there convincing evidence of a causal connection between GBS and vaccines? Consider this clinical scenario, then choose true from false.

Does a history of having contracted Guillan Barré syndrome (GBS) preclude someone from receiving certain vaccines? Which vaccines do you have to worry about? What is the evidence for a causal connection?         

In the following scenario, see if you think a contraindication is present.

A 12-year-old is in your office and needs a Tdap, HPV, inactivated flu shot, and quadravalent meningococcal vaccine. Her medical history is significant for GBS that began 4 weeks after she received Tdap, MMR, IPV, LAIV, and Varivax at age 5. She has recovered fully.

Which of the following statements is true?

A. GBS following any flu vaccine within 6 weeks after receipt is a contraindication to future flu vaccination
B. GBS within 6 wks of receipt of any tetanus toxoid-containing vaccine contraindicates future tetanus toxoid-containing vaccine
C. Both A and B are true
D. Neither A or B is true but are considered precautions, not contraindications
E. Meningococcal vaccines are listed as a precaution, not a contraindication
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