|Articles|January 29, 2011

Biomarker Directory

Biomarker: Putative molecular indicator of a specific biological state.1 Some biomarkers, called surrogate endpoints, are used as substitutes for actual clinical endpoints such as incidence of disease or death.2

Biomarker: Putative molecular indicator of a specific biological state.¹
Some biomarkers, called surrogate endpoints, are used as substitutes for actual clinical endpoints such as incidence of disease or death.²

ACE
adiponectin
androgen receptor gene (AR)
BRCA1
CFH
CYP2C9
DDE
estradiol
glycoprotein IIIa
G20210A

GSTM1

(Many more biomarkers to come shortly.)

Sources:

1. Bossuyt, Patrick M.M., The Thin Line Between Hope and Hype in Biomarker Research.JAMA 305(21):2229-2230. 2011.

2. Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease. Consensus Report, Institute of Medicine, National Academy of Sciences, May 2010.

3. Ioannidis, John P.A. and Orestis A. Panagliotous, Comparison of Effect Sizes Associated With Biomarkers Reported in Highly Cited Individual Articles and in Subsequent Meta-analyses.JAMA 2011:305(21):2200-2210.

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