Experts share an overview of IBS-C and CIC in adult patients and explore solutions for addressing the challenges leading to treatment discontinuation. They also discuss the impact of variable onset of individual abdominal and bowel symptom response, as well as the role of adverse effects on treatment adherence in patients with IBS-C and CIC. And finally, they review strategies for setting treatment expectations and highlight the importance of an effective patient-provider relationship and optimizing long-term clinical outcomes for these chronic conditions.