January 3rd 2025
In November 2024, an FDA advisory committee said the benefits of sotagliflozin do not outweigh the risks in adults with type 1 diabetes and chronic kidney disease.
Bilateral Knee and Thigh Pain in a Woman With Uncontrolled Type 2 Diabetes
June 6th 2014A 50-year-old African American woman with type 2 diabetes mellitus and hypertension was admitted with bilateral knee and thigh pain and swelling of both knees. MRI showed extensive edema in the distal thigh and gastrocnemius muscles and in subcutaneous fat. Fluid was seen at the short head of the left biceps femoris. The findings were consistent with diabetic myonecrosis. Which of the following statements about this condition is/are true?
Low Testosterone Syndrome Rx: Still Waiting for Godot
September 27th 2013A little bit of knowledge can be a dangerous thing, and I am proof. There is a lot more to the saga and much of the information is essential to decision making in primary care practice on whether or not testosterone replacement is indicated.
Fibroblast Growth Factor 23: A Novel Risk Factor for CVD in Chronic Kidney Disease
February 28th 2013The news: elevated levels of FGF are a new risk factor for death in chronic kidney disease-a clinical situation replete with cardiovascular disease. Here: how practice should change in the face of these newly identified nontraditional cardiovascular risk factors in CKD.
Hairy Hyperpigmented Lesion on a Teenager’s Back
September 9th 2010A 16-year-old boy with asymptomatic, hyperpigmented, hairy lesion on his left upper back. The pigmentation, first noted 5 years earlier, had progressively spread across his torso. The coarse and dark hair confined to the hyperpigmented area had appeared at age 13 years. Medical history uneventful. Review of systems showed no abnormalities. No family history of similar skin lesions.
Woman With Acromegaly Presenting as Unilateral Vision Loss
August 3rd 2010A 36-year-old woman presented to the emergency department with loss of vision in the right eye that had initially involved the peripheral field and progressed over 2 months to the central and nasal fields. During this period, she also had headaches, vomiting, and generalized weakness. She had had amenorrhea for 1 year.
ACCORD Study Shows Mixed Results for Strict Glycemic Control
July 16th 2010Intensive control of blood glucose levels reduces the development and progression of certain microvascular complications of type 2 diabetes but does not reduce cardiovascular risk, according to the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study investigators.