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Your daily dose of the clinical news you may have missed.

Intervention Cuts Alcohol Use in Youths with Chronic Medical Conditions: Daily Dose

Results from secondary analysis suggest future work is needed to extend the prevention intervention to address additional chronic conditions and substance use.

Disease-Tailored Preventive Intervention Reduces Alcohol Use in High-Risk Youths with Chronic Medical Conditions

Your daily dose of clinical news you may have missed.

Daily Dose: Osteoarthritis Estimated to Affect Nearly 1 Billion by 2050

Three key drivers of the perennial increase in OA prevalence are population growth, aging, and obesity, said authors of the analysis for the Global Burden of Disease study. 

Osteoarthritis Projected to Affect Nearly 1 Billion by 2050, Obesity a Major Contributing Factor 

Investigators report a 30% reduced risk of total joint replacement in persons with type 2 diabetes treated with metformin vs those who did not receive the drug. 

Metformin Treatment in T2D Patients May Reduce Risk for Joint Replacement: Population-based Study

Among medical cannabis users relief of pain from a variety of conditions is one of the most common reasons given for its use. Studying the efficacy of cannabis on pain is an area of research that is still very much in infancy and without the support of sizable public or private grants. And even though legalization has been steady for both medical and recreational use of cannabis, it is still a US DEA schedule 1 substance, hard to procure for research, and for many, still carries an aura of illegitimacy.

For researchers looking at the potential for cannabis to play an increasing role in medicine and health and wellness, the foregoing is their reality but certainly not a deterrent.  

 both run laboratories in the Department of Psychology at Washington State University that are looking at the effects of cannabinoids on the preclinical level (Dr Craft) and on a wide range of physical and psychological domains (Dr Cuttler). They are coauthors, most recently, on 2 studies on the acute and long-term effects of inhaled cannabis on 

pain.

Using data from many thousands of cannabis use sessions recorded in a medical cannabis app, Cuttler, Craft, and colleagues analyzed whether cannabis use decreased pain and whether factors such as gender, type of cannabis, THC, CBD or dose contribute to changes in pain ratings.



In this video, Patient Care Online talks with Drs Cuttler and Craft about their laboratories, their research, the study results, and about the challenges and the rewards of studying cannabinoids. 

Videos

Cannabis researchers Drs Carrie Cuttler and Rebecca Craft discuss their findings, their labs at WSU, their new research, and what makes this kind of research a challenge. 

Two Cannabis Researchers Discuss their Studies on Pain and the Realm of Cannabinoid Investigation 

After analyzing data from thousands of documented cannabis-use sessions for acute pain from a variety of conditions,* Drs Carrie Cuttler and Rebecca Craft from the Department of Psychology at Washington State University identified trends in diminished analgesic efficacy for some pain states over time as well as use of larger doses of cannabis over time.

In this video the researchers discuss issues of tolerance and what the observed increase in dose across time might indicate.

from >12 000 cannabis use sessions for treating headache and >7000 cannabis use sessions for treating migraine that spanned a period of 6 months.

from >57 000 cannabis use sessions for treating muscle pain, >56 000 cannabis use sessions for joint pain, and >17 000 sessions for nerve pain that spanned a period of 34 months.

For the other videos in this interview series:

Impact of Inhaled Cannabis for Acute Pain: Analysis of a Unique Data Set

Cannabis, Pain Relief, and the Sexes: Differential Benefit Explored

Authors of 2 large cannabis-user database analyses discuss the possible reasons for observed dose increase over time by individuals using inhaled cannabis for pain relief. 


Analysis of Cannabis for Pain: Is Tolerance an Issue? 

In their research on the impact of inhaled cannabis on acute pain relief for headache and migraine and for muscle, joint, and nerve pain, Drs Carrie Cuttler and Rebecca Craft from the Department of Psychology at Washington State University, assessed the influence of sex on degree of relief of pain from the various conditions.

The findings were a surprise, for a variety of reasons. In this video, Dr Craft discusses the results.

from >12 000 cannabis use sessions for treating headache and >7000 cannabis use sessions for treating migraine that spanned a period of 6 months.

In the second study, the team

For the other videos in this interview series: 

Analysis of Cannabis for Pain: Is Tolerance an Issue?

The following transcript has been edited lightly for clarity. 

 I'd like to go a little more into the differences by sex and ask Dr Craft about the implications of those results and whether they also mirrored results that you see in your preclinical studies?

 I think we were actually kind of surprised, at least in the first study, by the gender difference that we saw, because the animal studies that my laboratory has done and a few others suggest that THC, at least, is more potent in producing pain relief in females. So we actually predicted that women would report that cannabis was more effective compared to men. But in fact, we got the opposite.

In animal models, pain relief from cannabis has been found to be greater in females; new research on pain relief from inhaled cannabis in regular users found something different. 

Cannabis, Pain Relief, and the Sexes: Differential Benefit Explored 

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