April 3rd 2025
Your daily dose of the clinical news you may have missed.
April 1st 2025
Semaglutide 2.4 mg significantly lowered the risk of MACE and mortality in patients with ASCVD and overweight or obesity but without diabetes, researchers reported.
March 31st 2025
March 26th 2025
Data from the phase 2 VENTURE-Oral Dosing Trial of VK2735 is expected in the second half of the year, the company said.
March 21st 2025
Update on Blood Pressure Screening for Children
There is not enough evidence to assess the benefit or harm, according to an update from the U S Preventive Services Task Force.
Growing Pains?
Has this teen been abused? Cast your votes and see if you’ve answered this and the 4 other questions in this week’s quiz correctly.
Brain and Nervous System Disorders: 11 Things to Keep in Mind
Neurological disorders have been considered a significant threat to public health for some time. Take a look at these facts and figures.
Wellens Syndrome
ECG findings that are specific for high-grade stenosis of the proximal left anterior descending (LAD) coronary artery.
Postprandial Pain in a 66-Year-Old Woman
Epigastric pain after meals occurs in the absence of physical or laboratory abnormalities in a 66-year-old woman slated for surgery.
For Persistent GERD Symptoms, What Next?
The GERD symptom of regurgitaton does not typically respond to acid suppressants.
For Recalcitrant GERD Symptoms, Order 24-h pH/Imepdance Study
Persistent GERD symptoms such as regurgitation may indicate poor response to PPI therapy.
Type 2 Diabetes and Medication Adherence: Where is the Disconnect?
Incretin drugs, which offer ease of use, very little hypoglycemia, and no weight gain (or even weight loss) seem to be an ideal therapy. But 80% to 90% of patients don’t stay on them. Why not?
Fish Oils and Prostate Cancer: Unraveling the Confusion
It is vital to acknowledge trusted sources and avoid being misguided by faulty research and sensationalized headlines.
Persistent Duodenal Ulcers: Order a Serum Gastrin Next
Elevated serum gastrin will help confirm the presence of gastrinoma or multiple endocrine neoplasia type 1.
Gestational Diabetes Increases Risk of Sleep Apnea
The risk of obstructive sleep apnea is increased nearly 7-fold in pregnant women with gestational DM, according to a study that used polysomnography to evaluate sleep quality.
Obstructive Sleep Apnea Linked to Increased Risk for Glaucoma
OSA is not simply a marker for poor health but is an independent risk factor for open-angle glaucoma. Both conditions affect millions worldwide.
Not a Risk Factor for Clostridium difficile Infection?
Previous antibiotic use and hospitalization are well known risk factors for C difficile infection. Are age, PPI use, immunosuppression, and BMI all also risk factors?
Risk Factors for Clostridium difficile Infection?
Age; proton pump inhibitor us; immunosuppression; BMI: which of these is not a risk factor for Clostridium difficile infection?
All About Gout: 10 New Ways to Beat an Old Foe
Becoming familiar with recent developments in managing “the king of diseases and the disease of kings” may help.
Weight Loss and Abdominal Pain in Diabetic Man: What Test?
What study would you order to determine the cause of progressively worsening crampy abdominal pain and unintentional weight loss in an older patient with diabetes?
Sitophobia and Chronic Mesenteric Ischemia in Older Diabetic Man
The clinical presentation-crampy abdominal pain after meals, weight loss, and loose stools-is consistent with chronic mesenteric ischemia given this patient's history of diabetes.
Genes Linked to Asthma More Active in Obese Patients
Simple weight reduction may improve the management of asthma in obese patients, according to a new study
Chronic GERD: Who and When to Screen for Barrett Esophagus
Barrett screening is controversial, but the American College of Gastroenterology supports this step in Caucasian men older than 50 with long-standing disease.
Chronic GERD: What’s Your Next Step?
GERD of long-standing duration may require on-demand PPI dosing-and evaluation for esophageal damage.
Artificial Sweeteners-Are They Better Than Sugar?
Artificial sweeteners are associated with both weight gain and weight loss and a counterintuitive effect on human physiology.
Defining Diabetes With Data: 10 Things That Are Good to Know
To gain a better understanding of this national and global epidemic and its impact, consider these key facts and figures.
Poor Sleep Affects Skin Aging and Function
Add skin health to the list of medical conditions that are affected by poor sleep. Sun protection should be emphasized in skin care.
The Safety of Incretin Therapy: Are Barriers Beginning to Fall?
Incretin-based T2DM therapy is not a direct cause of pancreatitis or pancreatic cancer asserts the European Medicines Agency.
Low-Risk Lifestyle Protects Against Coronary Events, All-Cause Mortality
All-cause mortality was 80% lower among subjects who maintained normal weight, ate moderately, exercised, and did not smoke compared with those who followed none of these habits.
Sleep-Deprived Teens Make Poor Dietary Choices
Those who sleep more also have healthier food habits, which may affect long-term health outcomes, such as obesity, diabetes, and heart disease.
Snoring
Snoring is a hallmark symptom of OSA and so serves as an early warning sign of potential morbidiy and mortality.
Pulmonary Embolism Presenting With Right Flank Pain
Pulmonary embolism was the diagnosis in these 3 women, each of whom presented with positional right flank pain.
Diabetes Intervention Trims Weight, Not Cardiovascular Events
Although this study did not show benefits for heart disease, it has shown that weight loss improves many other health problems.
ADA Take-Aways: Assail Obesity, Stay the Course With Incretins
Bariatric surgery is recommended along with oral therapy to help patients with type 2 diabetes control overweight and obesity.