Duane M. Smith, MD

A 24-year-old man with a history of HIV infection (CD4+ cell count, 746/µL [32%]; HIV RNA level, 980 copies/mL; nadir CD4+ cell count, 482/µL [29%]), secondary syphilis, major depression, and intermittent crystal methamphetamine use presented to the emergency department with a 1-week history of gradually increasing pain and swelling in the left side of his scrotum, 2 days of fever (temperature to 38.6°C [101.5°F]), and chills.

A 22-year-old man with a history of AIDS, gastritis, and perianal warts presented to his primary care physician with a complaint of worsening dyspepsia and diarrhea.