Editorial Comment: HIV Testing in Prisons and Jails-Providing the Carrot With the Stick
September 2nd 2007Treatment of HIV infection reduces the risk of transmission and can significantly improve patients’ quality of life. For these reasons, the CDC has recommended routine screening for HIV in all health care settings.1 HIV testing access in correctional facilities is the weakest link in the fight against HIV infection in the United States; increasing access to testing would improve the identification of HIV-positive inmates as they pass through prisons and jails, providing an opportunity to integrate them into the public health infrastructure of HIV care. However, numerous logistical and cost-related barriers to such testing must be addressed when determining how and when it should be conducted.
Editorial Comment: Wanted-Noninvasive Interventions for Lipodystrophy in HIV-Infected Children
September 1st 2007Miller1 reports the results of a 3-month program of progressive resistance and aerobic exercise training in 2 perinatally HIV-infected girls: a normal-weight 10-year-old and an overweight 17-year-old. By the end of the program, both had decreases in body mass index (BMI); lost fat, including visceral fat, by at least some measures; and gained significant muscle strength. One had improved cardiovascular fitness, and both showed further improvements after completing a home-based program after the initial 12-week program.
Comparing 2 antifungals in patients with invasive candidiasis
September 1st 2007In a phase 2 study, the new echinocandin anidulafungin was demon-strated to be effective in the treatment of invasive candidiasis. Additional encouraging findings have recently been reported by Reboli and coworkers, who compared anidulafungin with fluconazole in a randomized, double-blind, noninferiority trial. The study included patients 16 years or older who had invasive candidiasis; 89% had candidemia only. They were randomly assigned to receive either intravenous anidulafungin or intravenous fluconazole. After 10 days of intravenous therapy, the patients could receive oral fluconazole.
Dorsal Dislocation of the Fourth and Fifth Metacarpals
September 1st 2007Several hours after striking his closed fist against the side pillar of a passenger car, a 28-year-old man presented with acute pain and swelling of the left hand. The dorsum of the left hand appeared deformed and edematous; there were scattered abrasions but no lacerations, exposed bony fragments, ecchymosis, or active bleeding.
Porphyria Cutanea Tarda in a Construction Worker
September 1st 2007For several months, a 55-year-old white construction worker experienced intense burning of the skin when exposed to direct sunlight. In addition, multiple fragile blisters appeared on the dorsa of his hands and arms; these rapidly developed into crusted, superficial erosions.
Willebrand's Disease or an Inherited Clotting Factor
August 31st 2007PRESTON, England -- From Addision's disease to Zollinger-Ellison syndrome, medical eponyms remain ubiquitous in the literature in favor of more scientific descriptions of disease. Now comes a proposal to do away with Down's and its ilk.
Campaign '08: Candidates Broaden Discussion at Armstrong Cancer Forum
August 30th 2007CEDAR RAPIDS, Iowa -- Only six of the 17 declared candidates for President showed up at a two-day forum designed to bring cancer care to the forefront of campaign issues, but the discussion broadened into questions of overall health care.
Missing Gene May Spark Imatinib Resistance in Philadelphia Chromosome-positive ALL
August 30th 2007MEMPHIS, Tenn. -- When imatinib (Gleevec) therapy fails in Philadelphia chromosome-positive acute lymphocytic leukemia (ALL), it may be because the B-cells involved lack a critical tumor suppressor gene, researchers here said.