New neffy (epinephrine nasal spray) Data To Be Shared in 9 Presentations at 2025 AAAAI

ARS Pharmaceuticals will present new data on neffy (epinephrine nasal spray) at the 2025 American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Scientific Meeting, February 28 - March 3, in San Diego, CA.

Courtesy ARS Pharmaceuticals

The novel needle-free alternative for the emergency treatment of type 1 allergic reactions, including anaphylaxis, received FDA approval in August 2024 and is indicated for use in adults and children who weigh at least 66 lbs, according to a an ARS statement.

ARS has planned 9 presentations, including an oral presentation on a study in Japanese patients comparing neffy with traditional intramuscular autoinjectors, antihistamines, and inhalers during an oral food challenge. The topline findings showed that study participants receiving neffy had lower symptom scores within 10 minutes, an outcome that supports the nasal spray's potential for managing severe allergic reactions. Additional data will highlight neffy’s pharmacokinetics and pharmacodynamics across various populations and conditions, including allergic and infectious rhinitis, self-administration, and repeat dosing.

“We look forward to sharing additional findings from our comprehensive clinical research program with the broader allergy community at AAAAI and expect that the data will continue to build on the existing robust data on the efficacy and safety of intranasal epinephrine administration,” Sarina Tanimoto, MD, PhD, Co-Founder and Chief Medical Officer of ARS Pharma. “As one of the leading companies actively conducting research in this critical space, we remain committed to advancing the scientific knowledge base of epinephrine so we can contribute to the allergy community.”

March 1, 2025

Oral presentations
Time: 2:45 p.m. - 2:55 p.m. PST
Title: Superior Efficacy of Epinephrine Nasal Spray for the Relief of Symptoms Following an Oral Food Challenge
Speaker: Kyohei Takahashi, MD, MPH, PhD
Room: Convention Center, Upper Level, Room 6B
Poster ID: 571

Poster presentations

Poster Presentation #1
Time: 9:45 a.m. - 10:45 a.m. PST
Title: Pharmacokinetics and Pharmacodynamics of Single Dose of Epinephrine Nasal Spray and Manual Intramuscular Injections via HCP and Self-administration in Chinese Subjects Under Normal Conditions
Authors: Yun Liu, MD, Shumin Wang, PhD, Miao Yu, MD, PhD, Pingya Hu, MD, Richard Lowenthal, MSc, Sarina Tanimoto, MD, PhD
Poster ID: 297

Poster Presentation #2
Time: 9:45 a.m. - 10:45 a.m. PST
Title: Persistence to Treatment in Patients with Allergic Conditions Requiring Epinephrine Auto-Injector Prescription (EAI Rx)
Authors: Autumn Burnette, MD, Raffi Tachdjian, MD, Nicole M. Chase, MD, Sarina Tanimoto, MD, PhD, Ayman Kafal, PhD, MPH
Poster ID: 302

Poster Presentation #3
Time: 9:45 a.m. - 10:45 a.m. PST
Title: Pharmacokinetics of Epinephrine Nasal Spray under Various Conditions
Authors: David M. Fleischer, MD, John Oppenheimer, MD, David Bernstein, MD, Thomas B. Casale, MD, Jonathan M. Spergel, MD, Richard Lowenthal, MSc, Sarina Tanimoto, MD, PhD
Poster ID: 290

Poster Presentation #4
Time: 9:45 a.m. - 10:45 a.m. PST
Title: Difference in Physiology Between Adults and Children in Response to Epinephrine Administration
Authors: Matthew J. Greenhawt, MD, David M. Fleischer, MD, Thomas B. Casale, MD, Michael A. Kaliner, MD, Neetu Talreja, MD, Richard Lowenthal, MSc, Sarina Tanimoto, MD, PhD
Poster ID: 289

Poster Presentation #5
Time: 9:45 a.m. - 10:45 a.m. PST
Title: Understanding the Pre-Treatment Journey of Patients with Allergic Conditions: Insights from Patient Demographics and Diagnostic Pathways
Authors: Raffi Tachdjian, MD, Autumn Burnette, MD, Nicole M. Chase, MD, Sarina Tanimoto, MD, PhD, Ayman Kafal, PhD, MPH
Poster ID: 291

Poster Presentation #6
Time: 9:45 a.m. - 10:45 a.m. PST
Title: Pharmacokinetics and Pharmacodynamics of Single Dose of Epinephrine Nasal Spray and Manual Intramuscular Injection in Chinese Subjects Under Allergic Rhinitis Conditions
Authors: Jianting Wang, MD, PhD, Shumin Wang, PhD, Miao Yu, MD, PhD, Jiaowei Lu, MD, Richard Lowenthal, MSc, Sarina Tanimoto, MD, PhD
Poster ID: 318

Poster Presentation #7
Time: 9:45 a.m. - 10:45 a.m. PST
Title: Total Nasal Symptom Scores Remain Consistent in Response to Repeated Nasal Allergen Challenges
Authors: Anne K. Ellis, MD, Michael A. Kaliner, MD, Carlos A. Camargo, Jr., MD, DrPH, John Oppenheimer, MD, David Bernstein, MD, Thomas B. Casale, MD, Richard Lowenthal, MSc, Sarina Tanimoto, MD, PhD
Poster ID: 483

Poster Presentation #8
Time: 9:45 a.m. - 10:45 a.m. PST
Title: Pharmacokinetics and Pharmacodynamics of Repeat Dose of Epinephrine Nasal Spray and Manual Intramuscular Injection in Chinese Subjects Under Normal Conditions
Authors: Shumin Wang, PhD, Jianting Wang, MD, PhD, Miao Yu, MD, PhD, Jiaowei Lu, MD, Richard Lowenthal, MSc, Sarina Tanimoto, MD, PhD
Poster ID: 317