• CDC
  • Heart Failure
  • Cardiovascular Clinical Consult
  • Adult Immunization
  • Hepatic Disease
  • Rare Disorders
  • Pediatric Immunization
  • Implementing The Topcon Ocular Telehealth Platform
  • Weight Management
  • Screening
  • Monkeypox
  • Guidelines
  • Men's Health
  • Psychiatry
  • Allergy
  • Nutrition
  • Women's Health
  • Cardiology
  • Substance Use
  • Pediatrics
  • Kidney Disease
  • Genetics
  • Complimentary & Alternative Medicine
  • Dermatology
  • Endocrinology
  • Oral Medicine
  • Otorhinolaryngologic Diseases
  • Pain
  • Gastrointestinal Disorders
  • Geriatrics
  • Infection
  • Musculoskeletal Disorders
  • Obesity
  • Rheumatology
  • Technology
  • Cancer
  • Nephrology
  • Anemia
  • Neurology
  • Pulmonology

Acute Large B-Cell Lymphoma

Article

A 68-year-old man presented with diplopia, progressive dyspnea, leg swelling, weakness, night sweats, and a 9-kg (20-lb) weight loss. He had been healthy up until 2 weeks earlier, when the symptoms started. The patient's medical, social, and family history was noncontributory.

 

A 68-year-old man presented with diplopia, progressive dyspnea, leg swelling, weakness, night sweats, and a 9-kg (20-lb) weight loss. He had been healthy up until 2 weeks earlier, when the symptoms started. The patient's medical, social, and family history was noncontributory.

Wael A. AlJaroudi, MD, of Duke University Medical Center, Durham, NC, reports that the patient had left sixth nerve palsy, a normal thyroid gland, a palpable epigastric mass, and no testicular masses. An MRI scan of the brain showed no evidence of stroke or tumor. An electromyogram was negative for myasthenia gravis.

A chest film revealed a mediastinal mass (A, arrow). A CT scan of the chest showed a mass (7.2 3 4.8 cm) that eroded into the anterior right ventricle and likely involved the pericardium and that invaded the posterior aspect of the right atrium (B, arrow).Results ofa tissue biopsy revealed acute large B-cell lymphoma.

The differential diagnosis of anterior mediastinal mass includes the "4 Ts," better known as:

  • Thymoma.

  • Teratoma (germ cell tumors).

  • Thyroid cancer (also parathyroid adenomas).

  • "Terrible" lymphoma, as in this patient.

Less common causes include connective tissue tumors, such as lipomas, liposarcomas, and sarcomas.

A lumbar puncture to rule out CNS involvement was planned, and an aggressive chemotherapy regimen was scheduled. However, 3 days later, cardiac arrest developed, and the patient died.

Recent Videos
New Research Amplifies Impact of Social Determinants of Health on Cardiometabolic Measures Over Time
Overweight and Obesity: One Expert's 3 Wishes for the Future of Patient Care
Donna H Ryan, MD Obesity Expert Highlights 2021 Research Success and Looks to 2022 and Beyond
"Obesity is a Medically Approachable Problem" and Other Lessons with Lee Kaplan, MD, PhD
© 2024 MJH Life Sciences

All rights reserved.