A PET/CT scan shows uptake of tracer consistent with malignancy in the left lower lobe and mediastinal nodes. What would be your next step?

A 20-year-old woman presents in mid-winter with a mildly painful, swollen, and discolored left toe of a week’s duration. What cause do you suspect?

This lesion in a previously healthy 40-year-old man, which was initially a small pustule, has enlarged into an open wound. What does this look like to you?

A 16-year-old boy had an asymptomatic, hyperpigmented, hairy lesion on his left upper back. What's your diagnosis?

The patient specifically reports difficulty swallowing at the level of the sternal notch. An upper endoscopy 10 years ago found no abnormality. Which of these tests makes sense now?

A 45-year-old man of Hispanic ancestry has had mild redness and irritation in both eyes, but he denies any change in vision. What is this?

A child receives a trivalent inactivated flu shot for his first ever flu vaccine. For his second dose, you only have on hand the quadrivalent live attenuated nasal vaccine. Is this a problem?

A young woman with a history of a desmoid tumor as a child undergoes a screening colonoscopy. What gene mutation is suggested by the finding of multiple adenomatous polyps?

This mobile tender nodule was discovered on the left wrist of a 60-year-old woman with a history of many non-melanoma skin cancers. What’s your best diagnostic guess?

A classic sign helps determine the diagnosis. Do you recognize it?

What to delete and what to keep, that is the IBS dietary question.

This lesion was treated in the primary care physician’s office. What treatment approach would you opt for?

Many treatments have failed but evidence is accumulating in support of a newcomer. Do you know which one it is?

Do you know what the ACIP says about mixing the zoster and varicella vaccines?

After a “swig” of Kaopectate, this patient noticed tongue discoloration. Is this coincidental, or is there a clinical connection?

From lacy and reticular and limited to the cheeks, this rash quickly covered the child’s body and transformed into a solid rash. Your dx?

For which of these patients would you give the 23-valent pneumoccocal vaccine?

Choroidal hemorrhage in the left orbit with retinal detachment: your dx?

What strategy will you choose to help cure this woman’s local rash?