Skin Diseases

The parents of a 6-year-old girl were concerned about the hyperpigmentation of their child’s fingers. Two weeks earlier, lime juice was accidentally spilled on the patient’s fingers during a barbecue on a sunny beach. By the following morning, the affected digits had turned red. A few days later, the erythematous areas became hyperpigmented.

Several lesions had appeared 1 week earlier on the left distal thigh of a 47-year-old woman. The affected area featured erythema with irregular faded borders and central redness with very fine papules over the L3 dermatome. The indurated and tender central areas suggested inflammation or necrosis. There were no vesicles and there was no drainage.

A painful, 4.8-cm nodule developed over 3 weeks on the face of a 76-year-old man. The results of a generous shave biopsy suggested a keratoacanthoma, a benign but locally destructive tumor that typically arises abruptly and enlarges rapidly. Curettage and desiccation were subsequently performed.

A 12-month-old infant is brought to your office for evaluation of ared, swollen left index finger, which her parents first noted the prior evening.The mother denies any known trauma or recent illness. She tells you that theinfant is slightly fussy and is not taking her bottle as well as usual.

The abrupt onset of widespread cutaneous eruptions prompted a 66-year-old man to seek medical evaluation. The patient had had chronic myelogenous leukemia for 5 years.

A network of purplish pink lesions recently developed on a 28-year-old woman’sarms and legs. The asymptomatic rash becomes more prominent with exposureto cold. The patient denies fever, aches, arthralgias, oral erosions, chestpain, and photosensitivity.

A 47-year-old woman who wasseropositive for HIV-1 presented tothe emergency department with severemaculopapular, erythematouseruptions. Her antiviral regimen hadrecently been changed from zidovudine, 300 mg bid; lamivudine, 150 mgbid; and saquinavir, 600 mg tid, tolamivudine, 150 mg bid; stavudine, 40mg bid; and nevirapine, 200 mg/d.

The sudden onset of a petechial rashon the upper and lower extremities,ecchymosis of the tongue, and anepisode of epistaxis prompted a78-year-old woman to seek medicalevaluation. She reported having takenone of her husband’s quinine pills aday earlier to alleviate leg cramps.The patient was otherwise in goodhealth and took no other medications.

This lesion on her knee had been present for 5 years, reported a 22- year-old woman. It was not related to any trauma; its size had not changed, but occasionally it became darker or lighter.

For 2 years, an asymptomatic mass had been present in the left iliac crest area of a 6-year-old boy. The soft, rubbery, lobulated mass was not attached to the overlying skin or to the underlying structures.

Leprosy, or Hansen disease, had recently been diagnosed in a 39-year-old man. He presented to the tropical disease unit of Harare Hospital, Zimbabwe, for follow-up.

A 72-year-old woman presented to the emergency department with epistaxis and generalized telangiectasia. The patient was known to have Rendu-Osler-Weber syndrome, or hereditary hemorrhagic telangiectasia, an autosomal dominant disorder that is associated with arteriovenous fistulae of many organs.

The sudden onset of a petechial rashon the upper and lower extremities,ecchymosis of the tongue, and anepisode of epistaxis prompted a78-year-old woman to seek medicalevaluation. She reported having takenone of her husband’s quinine pills aday earlier to alleviate leg cramps.The patient was otherwise in goodhealth and took no other medications.

Perspiration in areas of skin redundancy-such as under pendulous breastsand in the groin-can predisposepatients to irritant or candidal intertrigo.

Round, smooth, bald areas had recently developed on the neck and chin of a 32-year-old man. No other areas of the body were affected. The patient had a lifelong history of chronic anxiety.

I read with interest Michael Rothstein’s Practical Pointer,“No More (Foot) Fungus Among Us” (CONSULTANT, August2002, page 1185).

A 59-year-old woman presented for a routine physical examination. She had no physical complaints and took no medications. During the physical examination, bilateral, flat, slightly elevated, yellowish cutaneous lesions were noted above and below the skin folds of the patient's eyelids.

Cutaneous lesions can develop in anumber of pulmonary diseases, suchas tuberculosis and sarcoidosis, as wellas in other diseases that may have pulmonaryinvolvement, such as Wegenergranulomatosis, collagen vasculardiseases, varicella, and pneumococcalinfections. In many cases, knowledgeof the clinical and histologic characteristicsof the skin lesions associatedwith these diseases can greatly facilitatediagnosis.

A 32-year-old previously healthywoman presents to the emergencydepartment with skin lesions, suprapubicpain, and generalized myalgia of1 week’s duration. Trimethoprim-sulfamethoxazolefor a presumed urinarytract infection is prescribed, and thepatient is discharged. The symptomspersist; she is hospitalized 2 days later.

The family of a 50-year-oldalcoholic man brings him to youroffice. They are concerned abouthis health and note that they had notseen him for several months beforehe reappeared. The patient complainsof generalized weakness, fatigue, andbleeding gums.

ABSTRACT: Systematic palpation can detect a trigger point; often, muscle spasms or a nodule will be present. Injection of the trigger point with a local anesthetic usually reduces pain promptly; the procedure can also effect long-term pain relief and increased range of motion. However, pain may recur and even worsen 1 to 3 days after an injection-either because additional injections are needed or because the trigger point was not completely injected. To maintain pain relief and improve strength and range of motion in the affected muscle following injection, recommend stretching exercises, physical or massage therapy, or rest. Trigger point injections can be associated with adverse effects (eg, temporary numbness, injection site irritation, and dizziness); complications include vasovagal syncope, skin infection, and compartment syndrome.

For the past several weeks, a 54-year-old man has had progressivelyworsening abdominal pain and general achiness.He has no nausea, vomiting, diarrhea, or fever and no historyof trauma.

Satellite lesions are usually associated with Candidainfections but not with Bowen disease.

For 10 years, a 22-year-old woman had had an erythematous, translucent patch of grouped blisters on her left thigh. A recent increase in the size of the patch prompted the patient to seek treatment. There was no burning or tingling at the site. The patient reported that the erythema occasionally cleared; however, the blisters always remained. She denied fever, weight loss, and other constitutional symptoms.

Asymptomatic, enlarging growths had been present on the bottom of a 56-year-old woman’s feet for 3 years. The nodules initially arose-first on the left foot, then on the right-at the sites of blisters on the insteps after the patient had taken a long hike in uncomfortable boots.

An 87-year-old woman sought treatment of what she described as a “bite” of 1 month’s duration. The pink, nodular lesion on the dorsum of the left hand had central superficial ulceration with yellow crusting at the web space between the thumb and index finger.

A Young Boy With High Fever and LethargyA 5-year-old boy is brought to the emergency department(ED) by his parents. They report that, for thepast week, the child has had a high fever (temperatureup to 40oC [104oF]), generalized weakness, lethargy, andlack of appetite. The boy’s eyes are bloodshot and he hasrefused food and drink. The child has no history ofcough, shortness of breath, hematemesis, melena, headaches,vision problems, or seizures. He has not been incontact with sick persons, has not traveled abroad, doesnot have a pet, and is not taking any medications. His immunizations are up-to-date.

For 2 months, a 47-year-old woman experienced constipation, weakness, fatigue, and dry skin. She also complained of moderate weight gain and menorrhagia during the same period. The patient took no medications and denied any allergies.

Primary care providers are seeingan increasing number ofpatients who have snakes orbarbwire coiling around theirarms or gold rings danglingfrom their eyebrows and navels. Tattooingand body piercing are particularlypopular among adolescents andyoung adults-many of whom may notbe aware of the possible medical complicationsof these ancient practices.

Three carbon dioxide laser treatments were used to remove a 35-year-oldwoman’s tattoo (A). Four months after the procedures, significant scarringwas noted at the site (B).