Musculoskeletal Disorders

Psoriatic Arthritis develops in approximately 20% of patients who have psoriasis.

The manifestations of this multisystemdisorder range from relativelybenign, self-limited cutaneous involvementto severe, potentially fatal systemicillness. Skin lesions associatedwith lupus erythematosus (LE) areclassified histologically as LE-specificor LE-nonspecific.

Twenty-four hours after a car accident, a 47-year-old man with chronic low back pain-which had been diagnosed years earlier as "arthritis" of the spine-presented with back and chest pain and requested an opioid analgesic. The patient had a history of alcoholism and illicit drug use. Tenderness of the thoracic area was noted.

Persons with a systolic blood pressure (BP) of 120 to 139 mm Hg or a diastolic BP of 80 to 89 mm Hg are now considered, according to the latest Joint National Committee (JNC) report on hypertension.

ABSTRACT: When a patient presents with low back pain, ask about the location and quality of the pain, what makes the pain increase or decrease, associated symptoms, and risk factors. Clues to systemic causes of low back pain include fever; arthritis; iritis; signs and/or symptoms of GI disease, pelvic disease, or renal disease; tachycardia; and integumentary abnormalities. Perform a neurovascular evaluation as well as a detailed musculoskeletal examination. Imaging studies are not necessary for most patients initially. Acute therapy consists of the application of cold and heat and analgesics such as acetaminophen or an NSAID. Early exercise-not bed rest-is the cornerstone of treatment. Follow-up is mandatory: in 3 to 7 days for patients with severe pain, inconsistent findings, mild neurologic abnormalities, or a history of progres- sive symptoms; and in 10 to 14 days for patients with no neurologic compromise.

Consider a concentrated solution(10 mg/mL) of doxepin for patientswith fibromyalgia who experienceside effects with other tricyclics ateven 10-mg doses.

This 2-day-old infant was noted by Robert P. Blereau, MD, of Morgan City, La, to have duplication of the fifth toe with webbing between the two toes to the distal interphalangeal joint. There was a family history of polydactyly on the paternal side and syndactyly on the maternal side.

Bullae had recently appeared on the dorsa of the hands and fingers of a 46-year-old man. His medical history was significant for alcoholism, discoid lupus erythematosus (DLE), and hepatitis C. Systemic lupus erythematosus (SLE) was ruled out; the patient’s symptoms did not meet the American Rheumatism Association criteria for SLE.

ABSTRACT: Many patients with osteoarthritis (OA) try such complementary therapies as special diets, nutritional and herbal supplements, yoga, t'ai chi, magnets, and acupuncture-but only 40% of these patients tell their physicians. Glucosamine and chondroitin sulfate can produce at least symptomatic relief; in addition, glucosamine (1500 mg/d) may increase or stabilize cartilage in osteoarthritic knees. Alert patients to the potential toxicities of many herbal remedies, as well as the risks of harmful drug interactions and possible contaminants and impurities. Yoga postures may have a beneficial effect on knee OA; t'ai chi may reduce joint pain and swelling and increase mobility. Small studies have shown that applied pulsed electromagnetic fields can reduce pain and improve function in patients with chronic knee OA. Acupuncture has also been shown, in small studies, to alleviate the pain of OA. Autologous chondrocyte transplantation was recently approved for treatment of knee OA. The efficacy and safety of various types of gene therapy are currently being evaluated.

The diagnosis of osteoarthritis (OA) is primarily clinical. Key historical clues to idiopathic OA include patient age greater than 45 years, joint pain that increases with activity and is relieved with rest, morning stiffness of 30 minutes duration or less, and involvement of one or more of the following: hips, knees, cervical or lumbar spine, basilar thumb joints, interphalangeal joints of the hands, midfoot joints, and first metatarsophalangeal joints.

ABSTRACT: Topical agents can provide temporary relief from osteoarthritis symptoms with little or no risk. Acetaminophen is first-line oral therapy. Be alert for risk factors for NSAID-induced GI toxicity, such as concurrent use of prescription and OTC agents. Tramadol, narcotic analgesics, muscle relaxants, and antidepressants are options when NSAIDs are ineffective or contraindicated. Intra-articular injections of corticosteroids or hyaluronan are appropriate for patients who have a single joint exacerbation. Total knee and total hip arthroplasty are considered the most effective surgical interventions.

A 50-year-old manpresents to your office with severediscomfort in the great toe that began24 hours earlier. He denies any traumabut says that he may have hadsimilar symptoms many years before.He has no recent history of feveror illness. You aspirate fluid from thefirst metatarsophalangeal joint foranalysis.

In the United States, osteoporosis affects 12% to 28% of women over age 65 years. Among women who live to be 85, 50% will sustain an osteoporosis-related fracture. Hip fractures occur in 15% of these women, and vertebral deformities develop in 25%

ABSTRACT: A thorough history and physical examination can establish the diagnosis of tension headache; further evaluation is generally unnecessary. In contrast, the workup of cervicogenic headache includes standard radiographs, 3-dimensional CT, MRI, and possibly electromyography; nerve blocks may also be used to confirm the diagnosis. Episodic tension headache can be treated effectively by trigger avoidance, behavioral modalities, and structured use of analgesics. Reserve opioids for patients with intractable headaches. Chronic tension headache is treated primarily by prophylactic measures, such as antidepressants and anticonvulsants, and behavioral and physical therapy. Treatment options for cervicogenic headache include analgesics; invasive procedures, such as trigger point injections, greater or lesser occipital nerve blocks, facet joint blocks, segmental nerve root blocks, and diskography; spinal manipulation; and behavioral approaches.

Can cyclooxygenase (COX)-2 inhibitorsbe used to treat gout?

Prevention of and therapy for osteoporotic disorders in men have been virtually unexplored. Although osteoporosis in men is associated with significant morbidity and mortality, many clinical decisions must be based on extrapolation from data on osteoporosis in women.

A 76-year-old woman had a 40-year history of rheumatoid arthritis (RA). She had repeatedly refused treatment with disease-modifying drugs, including methotrexate. Nodules began to develop 15 years after the initial diagnosis; they recurred after surgical removal.

Numerous plaques, some with yellow crusting and central scarring, had erupted primarily on the face and neck of a 46-year-old man. A single lesion had developed on his left elbow as well. The lesions were initially diagnosed as impetigo, but they failed to resolve after 2 courses of oral cephalexin.

A 30-year-old man presented with a few-day history of aviral prodrome, including a low-grade fever, mild headache,muscle and joint aches, and malaise, accompaniedby a vesiculopapular rash. The mildly pruritic eruptionbegan on the head and neck and progressed within 36hours to the trunk and proximal extremities; the palmsand soles were spared.

The goal in managing manymusculoskeletal injuries isnow early mobilization-notimmobilization. This shift inemphasis encompasses injuriesranging from a strained backto a sprained ankle. Patients withsciatica who previously might havebeen kept at bed rest for severalweeks are now encouraged to avoidbed rest and to alleviate nerve irrita-tion with positional exercises. Similarly,patients with ankle sprainsgain faster pain relief and recoverfunction more rapidly when cast orsplint immobilization is avoided.Early mobilization is appropriate formany acute injuries without riskof significant bone or joint instability.Its advantages have emerged asthe many detriments or hazards ofeven brief periods of immobilizingmuscles, joints, and bones havebecome apparent.